Molecules {coenzyme}| can bind to enzymes to activate them. Michaelis and Wollman discovered that free radicals formed from alpha-tocopherol [1950]. Lipmann isolated coenzyme A [1945]. Mitchell, Snell, and Williams isolated folic acid [1941]. O'Kane and Gunsalus isolated lipoic acid [1948]. Metals can be coenzymes [1930]. Jansen and Donath isolated thiamine [1926]. Fildes hypothesized that molecules similar to natural substrates or coenzymes compete and are therapeutic. Methotrexate treats leukemia (Farber) [1946].
Physical Sciences>Chemistry>Biochemistry>Protein>Kinds>Enzyme
5-Chemistry-Biochemistry-Protein-Kinds-Enzyme
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Date Modified: 2022.0224