Bases A, C, G, and T can attach to N-(2-aminoethyl)-glycine {peptide nucleic acid} (PNA). PNAs have no electric charge, are more stable, and bind better to DNA or RNA than oligonucleotides do.
triplex
If PNA is all C or T and so is homopyrimidine, PNA strand can lie in double-stranded-DNA major groove and bind to double-stranded DNA {PNA-DNA triplex}. Two PNA strands can push away a DNA strand, which forms a loop, and make a triple-strand {triplex invasion}. PNA strand can bind to DNA strand, displacing but not removing other DNA strand {duplex invasion}. Two PNA strands can bind to opposite DNA-strand regions, displacing but not removing DNA strands {double duplex invasion}.
Physical Sciences>Chemistry>Biochemistry>Nucleic Acid>Kinds
5-Chemistry-Biochemistry-Nucleic Acid-Kinds
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Date Modified: 2022.0224