Compounds {drug, chemistry} {drug-like compound} can metabolize with biological molecule.
size
Drugs have molecular weight 200 to 700.
side effects
Drugs must have few side effects.
absorption
Body can absorb drugs.
distribution
Drugs can go to body organs and/or tissues.
metabolism
Drugs have chemical reactions at sites. Drugs have orientation at receptor site. Drugs can sterically interact with receptor site.
excretion
Drugs do not excrete too quickly.
solubility
Drugs have solubility, partition coefficients, diffusivity, and ionization degree.
variation
Drugs can vary using different salts, esters, and side groups for different sizes and surface areas.
form
Drugs can be solutions, suspensions, capsules, or tablets. They can be oral, subcutaneous, intravenous, inhaled, or patch.
history
In England, William Morton [? to 1868] used inhaled ether [1846] during surgery on October 16 (Ether Day). inhaled chloroform [1850]. inhaled nitrous oxide and oxygen [1868]. hypodermic syringe [1868]. intravenous morphine [1868]. chloral hydrate [1869]. inhaled nitrous oxide and oxygen followed by chloroform or ether [1876]. paraldehyde [1882]. cocaine [1884]. sulfones [1888]. ethyl p-aminobenzoate [1890]. Novocaine is procaine hydrochloride. Phenacetin comes from aniline by hydroxylation and conjugation [1890 to 1899]. aspirin [1899]. Anti-pyrine came from quinine [1900]. urethane [1900].
Physical Sciences>Chemistry>Biochemistry>Drug
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Date Modified: 2022.0224