Enzymes {adenylate cyclase} {adenylcyclase} can alter cAMP.
Enzymes {carboxylesterase} can catalyze phase I reactions.
Enzymes {cytochrome P-450} catalyze phase I reactions 3A4, 2D6, 2C9, 1A2, and 2E1.
Enzymes {epoxide hydratase} {epoxide hydrolase} can oxidize olefins and aromatics to make epoxide or oxirane metabolites. It can produce carcinogens.
Enzymes {glucuronyl-transferase} can catalyze phase II reactions, adding glucuronide to drugs.
Enzymes {glutathione-S-transferase}, in liver-cell cytoplasm, can catalyze phase II reactions to conjugate compounds to glutathione.
Enzymes {microsomal flavoprotein mono-oxygenase} can oxidize nitrogen or sulfur organics.
Enzymes {microsomal hydroxylase} can catabolize many compounds, mostly by oxidation, in endoplasmic reticulum.
Enzymes {mixed-function oxidase} (MFO) can catabolize many compounds, mostly by oxidation, in endoplasmic reticulum.
Enzymes {phospholipase A2} can catabolize lipids.
Enzymes {phospholipase C} can catabolize lipids.
Enzymes {protein kinase} can catabolize proteins.
Enzymes {uridine diphosphoglucose transferase} {uridine-diphosphate-glucuronosyl-transferase} (UDP-GT) (UGT) can catalyze phase II reactions, adding glucuronide to drugs.
5-Chemistry-Biochemistry-Drug-Metabolism
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Date Modified: 2022.0225