Claissen condensation

Acetyl-CoA reactions {Claissen condensation} can lengthen carbon chains by branching. Acetyl-CoA ketone, CH3-CO-S-CoA [3 is subscript], can lose hydrogen when CoA leaves, CH3-CO-, and separate charges to make (C-H2)-(C+O) [2 is subscript and - and + are superscripts]. Ketone carbon is positive, and methyl carbon is negative. Separated charges attack dicarboxylic acid, HOOC-CH2-COOH [2 is subscript], to add ketone, HOOC-(CH2C-H2C+O)-COOH [2 is subscript and + and - are superscripts]. Adding water molecule neutralizes carbon and makes branched carbon chain, HOOC-CHCH2COOH-COOH [2 is subscript], as hydrogen gas leaves.

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