At high concentrations, cAMP-dependent protein-kinase catalytic subunits {cAMP-dependent protein kinase} phosphorylate transcription factors, such as cAMP-response element binding protein-1 (CREB-1), C/EBP transcription factor, and tissue plasminogen activator (tPA), which express genes in cell nucleus to initiate change or growth. Repeated action potentials, from stress or high activity, make cAMP-dependent protein kinase concentration high.
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Date Modified: 2022.0224