G-protein-coupled receptor

Outer-membrane receptors {G-protein-coupled receptor} (GPCR) can have seven alpha helices in cell membrane and has active protein part inside cell membrane next to G protein. For example, olfactory sense neurons have membrane receptors that activate G protein. For slow 0.1-second to 10-second effects, receptor activates G protein, which binds GTP to make second messengers such as cyclic AMP, diacylglycerol (DAG), or inositol triphosphate (IP3), which phosphorylate ion channels.

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