Helper T cells {regulatory T cell} {CD4+CD25+ T cell} {T-reg cell} {T regulatory cell} can inhibit helper-T-cell immune responses, rather than secrete cytokines or engulf infected cells. 5% to 10% of CD4+ T lymphocytes are regulatory T cells.
receptors
Regulatory T cells have T-cell receptors, CD4-protein receptors, and CD25 surface proteins, which are in interleukin-2 receptors. Interleukin-2 excites regulatory T cells.
transcription
They have Foxp3 transcription-factor protein, which makes molecules that can disable autoreactive T cells.
Perhaps, antigen-specific receptors are stronger than the ones for autoreactive CD4+ T lymphocytes. Perhaps, regulatory T cells inhibit antigen-presenting cells from showing antigen. Perhaps, regulatory T cells cause antigen-presenting cells to release inhibitory cytokines. Perhaps, regulatory T cells inhibit autoreactive CD4+ T lymphocytes directly.
problems
Foxp3-gene mutation can cause immune dysregulation polyendocrinopathy enteropathy X-linked chromosome syndrome {IPEX syndrome} and autoreactive immune systems. Scurfy mice have autoreactive immune systems.
Biological Sciences>Zoology>Organ>Immune System>Cells>T Cell
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Date Modified: 2022.0224