gene therapy

Altered cells can go into body {gene therapy}|. Gene therapy can repair genes by recombining with good gene, adding good gene, or blocking RNA by antisense molecules or ribozymes.

types

Bone-marrow hematopoietic cells that make blood cells can grow in culture, where retroviruses change them for return to bone marrow.

Skin fibroblast cells can grow in culture for return under skin or to peritoneum.

Liver hepatocyte cells can grow in culture for return to liver, spleen, or portal vein.

Skeletal-muscle-tissue stem-cell satellite cells that remain beside muscle fiber can regenerate. They can grow in culture for return to muscle. Most skeletal-muscle-tissue stem-cell myoblasts fuse to make multinucleate muscle fibers.

Retroviruses can infect living blood-vessel-lining endothelia using catheters or lung-lining cells using aerosols.

Lymphocytes {tissue-infiltrating lymphocyte} (TIL) can enter solid tumors and kill them if interleukin-2 lymphocyte growth factor is present.

T cells modified with adenosine-deaminase gene help children with severe combined immunodeficiency.

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