phenylketonuria

Enzyme deficiency causes inability to make phenylalanine into tyrosine and results in toxicity affecting gait and posture {phenylketonuria}| (PKU). Enzyme deficiency also causes inability to metabolize phenyl pyruvate, and excess blood phenyl pyruvate causes mental retardation. PKU affects one in 10,000 births. Diets low in phenylalanine can prevent PKU.

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