Dominantly inherited disorders {Huntington's chorea} {Huntington chorea} {Huntington's disease} can result from expanded glutamine repeats in HD proteins.
symptoms
At first, patients fidget, have spontaneous movements, and appear clumsy. Later, jerking and writhing affect face, tongue, and arms.
biology
A chromosome-4-tip autosomal dominant gene can cause Huntington's chorea. Cytosine-adenine-guanine nucleotides {CAG repeat, Huntington's} repeat in middle too many times, making too many glutamines. Proteins clump together {polyglutamine disease, Huntington's} to make protofibrils and later plaques. Cerebrum shrinks, ventricles enlarge, and midbrain caudate nucleus and putamen have damage. Cytosine-anything-guanine regions {CxG region, Huntington's} make DNA hairpins, so copies are longer.
Biological Sciences>Medicine>Disease>Kinds>Organ>Nerve>Muscle>Chorea
4-Medicine-Disease-Kinds-Organ-Nerve-Muscle-Chorea
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Date Modified: 2022.0224