Gene {Notch gene} products can activate signaling pathways and regulate whether neural precursors become neurons or glia. Enzymes cleave Notch and APP transmembrane proteins in membrane plane {regulated intramembrane proteolysis}, to liberate cytosolic fragments, which enter cell nucleus to control gene transcription. Regulated intramembrane proteolysis is similar from bacteria to humans.
Gene {Bmi-1 gene} products can activate signaling pathways.
Gene {Wnt gene} products can activate signaling pathways.
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Date Modified: 2022.0225