adrenergic receptor

Alpha-adrenergic and beta-adrenergic cell-surface receptors {adrenergic receptor} can bind epinephrine and similar compounds.

membrane

Amino ends are outside membranes, and carboxyl ends are inside membranes. Seven helices pass through membrane.

functions

Adrenergic receptors can couple to G protein. Adrenergic receptors can activate or inhibit adenylate cyclase to make or decrease cAMP.

functions: phosphates

Adrenergic receptors can activate phospholipase to break down inositol phospholipids in membrane into inositol triphosphate and diacylglycerol. Inositol triphosphate makes calcium vesicles release calcium ions, which bind to calmodulin, which regulates enzymes such as protein kinase. Diacylglycerol activates protein-kinase C proteins. Phosphorylation causes conformational changes that expose active sites and activate protein kinases. Protein phosphatases, such as cytoplasmic CD45 membrane protein, remove phosphates.

Whole Section in One File

4-Genetics-Gene-Cell Surface Receptor

Drawings

Technical Information

Date Modified: 2022.0224