Cell-cell binding {adhesion, cell}| involves cell-membrane proteins, such as integrins, cadherins, Deleted in Colon Cancer (DCC), and CEA.
B-integrin and twenty similar proteins {integrin} are transmembrane receptors for weak-binding glycoprotein adhesion molecules, such as extracellular-matrix fibronectin, collagen, vitronectin, and laminin. Inside cells, integrins link to cytoskeleton talin, vinculin, and actin microfilaments. Alpha-integrin maintains long-term potentiation (LTP) and aids memory.
E-cadherin, P-cadherin, and N-cadherin proteins {cadherin} are calcium adhesion molecules (CAM). E-cadherin is 120 kDa, spans cell membrane, and connects with catenins that link to cytoskeleton actin. Cancer cells have low cadherin and low intercellular adhesion. Protocadherin affects brain development.
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Date Modified: 2022.0225