Double-layer membranes {phagophore} can form in cytoplasm. Phagophores increase if nutrients, growth factors, and/or oxygen have low concentration.
process
Phagophore membranes close around damaged cell molecules and make spheres {autophagosome}. Autophagosome formation needs apg8 protein, similar to ubiquitin, which undergoes phosphoglycerolipidation with phosphatidylethanolamine to integrate into membrane. Ubiquitin recognizes and binds damaged proteins, marking them for later break down.
lysosomes
After autophagosome formation, membrane proteins leave, and autophagosomes fuse with cell lysosomes. Lysosomes contain lysozyme, which removes sugars from proteins and catabolizes {autophagy, autophagosome} large molecules, such as membranes and poorly folded, denatured, foreign, damaged, or used proteins.
Biological Sciences>Cell>Organelle>Microsome>Lysosome
4-Cell-Organelle-Microsome-Lysosome
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Date Modified: 2022.0224