pain physiology

Pain control is at first synapse, near spinal cord {pain, physiology}. Prostaglandins block glycine receptors and so excite dorsal-horn neurons. More and wider brain activation indicates more pain [Chapman and Nakamura, 1999]. Drugs can make pain feel pleasurable. The fundamental pain characteristic is repulsion or withdrawal, and the fundamental pleasure characteristic is attraction or advance [Duncker, 1941].

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